Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …

An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is
introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

The contractility of cardiac cells is a key parameter that describes the biomechanical
characteristics of the beating heart, but functional monitoring of three-dimensional cardiac …

In vitro models incorporating the complexity and function of adult human tissues are highly
desired for translational research. Whilst vital slices of human myocardium approach these …

Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Rationale: Preclinical testing of cardiotoxicity and efficacy of novel heart failure therapies
faces a major limitation: the lack of an in situ culture system that emulates the complexity of …