The role of carbohydrates in the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signalling

F Cochet, F Peri - International journal of molecular sciences, 2017 - mdpi.com
The interactions between sugar-containing molecules from the bacteria cell wall and pattern
recognition receptors (PRR) on the plasma membrane or cytosol of specialized host cells …

[HTML][HTML] Lipopolysaccharide structure and the phenomenon of low endotoxin recovery

A Gorman, AP Golovanov - European Journal of Pharmaceutics and …, 2022 - Elsevier
Lipopolysaccharide (LPS) is a cell-wall component of Gram-negative bacteria which
contributes to bacterial toxicity. During processes such as cell division, shedding of outer …

Candidalysin is a fungal peptide toxin critical for mucosal infection

DL Moyes, D Wilson, JP Richardson, S Mogavero… - Nature, 2016 - nature.com
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial
pathogens which disrupt epithelial barrier function, damage cells and activate or modulate …

A TLR4-independent critical role for CD14 in intracellular LPS sensing

SO Vasudevan, AJ Russo, P Kumari, SK Vanaja… - Cell reports, 2022 - cell.com
Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome
comprising caspase-4 or-11 governs antibacterial host defense. How LPS gains intracellular …

Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion

AB Schromm, K Brandenburg… - European journal of …, 2000 - Wiley Online Library
Lipopolysaccharide (LPS) represents a major virulence factor of Gram‐negative bacteria
('endotoxin') that can cause septic shock in mammals including man. The lipid anchor of LPS …

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

A Poltorak, P Ricciardi-Castagnoli… - Proceedings of the …, 2000 - National Acad Sciences
Some mammalian species show an ability to discriminate between different
lipopolysaccharide (LPS) partial structures (for example, lipid A and its congener LA-14-PP …

Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation

L Mashburn‐Warren, J Howe, P Garidel… - Molecular …, 2008 - Wiley Online Library
Bacteria have evolved elaborate communication strategies to co‐ordinate their group
activities, a process termed quorum sensing (QS). Pseudomonas aeruginosa is an …

Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells

T Gutsmann, M Müller, SF Carroll… - Infection and …, 2001 - Am Soc Microbiol
The lipopolysaccharide (LPS)-binding protein (LBP) has a concentration-dependent dual
role in the pathogenesis of gram-negative sepsis: low concentrations of LBP enhance the …

Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14-and TNF-dependent mechanisms

G Chen, J Li, M Ochani… - Journal of leukocyte …, 2004 - academic.oup.com
Abstract Bacterial endotoxin [lipopolysaccharide (LPS)] stimulates macrophages to
sequentially release early [tumor necrosis factor (TNF)] and late [high mobility group box 1 …

[HTML][HTML] The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: A physico-chemical study with lecithin phospholipids

MM Moreno, P Garidel, M Suwalsky, J Howe… - … et Biophysica Acta (BBA …, 2009 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) represent non-specific inhibitors of the
cycloxygenase pathway of inflammation, and therefore an understanding of the interaction …