Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …

Apoptotic cell clearance by macrophages (efferocytosis) promotes resolution signaling
pathways, which can be triggered by molecules derived from the phagolysosomal …

The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of
inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct …

Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular
physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly …

This review aims to summarize the current knowledge of molecular pathways and their
clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent …

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein,
which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a …

Dysregulation of the AXL receptor tyrosine kinase has been associated with many types of
cancer. It has not been until recently, however, that targeting AXL has come under the …

Inflammation resolution counterbalances excessive inflammation and restores tissue
homeostasis after injury. Failure of resolution contributes to the pathology of numerous …