The emerging evidence on the interconnectedness between the gut microbiome and host
metabolism has led to a paradigm shift in the study of metabolic diseases such as obesity …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Neutrophils are the most abundant innate immune cells in the circulation and they are the
first cells recruited to sites of infection or inflammation. Almost half of the intracellular protein …

Amplification of innate immune responses by endogenous danger‐associated molecular
patterns (DAMPs) promotes inflammation. The involvement of S100A8 and S100A9, DAMPs …

The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …

Atherosclerosis is an arterial disease associated with dyslipidemia, abnormal arterial
calcification and oxidative stress. It has been shown that a continued chronic inflammatory …

Inflammation primarily influences the initiation, progression, and deterioration of many
human diseases, and immune cells are the principal forces that modulate the balance of …

Objective—The S100 alarmins A8, A9, and A8/A9, secreted by activated neutrophils and
monocytes/macrophages, are involved in the pathogenesis of various inflammatory …

The number of diabetic patients in Europe and world-wide is growing. Diabetes confers a 2-
fold higher risk for vascular disease. Lack of insulin production (Type 1 diabetes, T1D) or …

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent and slow progressing hepatic
pathology characterized by different stages of increasing severity which can ultimately give …