[HTML][HTML] Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …
functioning associated with the disorder and are not responsive to existing treatments. In this …
[HTML][HTML] The role of prefrontal cortex in cognitive control and executive function
NP Friedman, TW Robbins - Neuropsychopharmacology, 2022 - nature.com
Abstract Concepts of cognitive control (CC) and executive function (EF) are defined in terms
of their relationships with goal-directed behavior versus habits and controlled versus …
of their relationships with goal-directed behavior versus habits and controlled versus …
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …
Single-cell transcriptomic analysis of Alzheimer's disease
Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …
Monolithic perovskite tandem solar cells: a review of the present status and advanced characterization methods toward 30% efficiency
Tandem solar cells are the next step in the photovoltaic (PV) evolution due to their higher
power conversion efficiency (PCE) potential than currently dominating, but inherently limited …
power conversion efficiency (PCE) potential than currently dominating, but inherently limited …
Brain cell type–specific enhancer–promoter interactome maps and disease-risk association
Noncoding genetic variation is a major driver of phenotypic diversity, but functional
interpretation is challenging. To better understand common genetic variation associated with …
interpretation is challenging. To better understand common genetic variation associated with …
[HTML][HTML] Genome-wide association studies of brain imaging phenotypes in UK Biobank
The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
The genetics of human ageing
The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …
Sustaining longer lives with reduced periods of disability will require an understanding of the …
[HTML][HTML] Genetic drug target validation using Mendelian randomisation
AF Schmidt, C Finan, M Gordillo-Marañón… - Nature …, 2020 - nature.com
Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …
relevance of environmental and biological risk factors for disease. However, causal …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …