This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where
blood flow pattern is disturbed rather than being laminar, and wall shear stress has an …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are
the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in …

Atherosclerosis underlies the predominant number of cardiovascular diseases and remains
a leading cause of morbidity and mortality worldwide. The development, progression and …

The shear-responsive transcription factor Krüppel-like factor 2 (KLF2) is a critical regulator of
endothelial gene expression patterns induced by atheroprotective flow. As microRNAs …

Rationale for Study: MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein
expression at post-transcriptional level. We hypothesized that a specific pool of endothelial …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …