International guidelines for groin hernia management

Hernia, 2018 - Springer
Introduction Worldwide, more than 20 million patients undergo groin hernia repair annually.
The many different approaches, treatment indications and a significant array of techniques …

Polypropylene pelvic mesh: What went wrong and what will be of the future?

A Seifalian, Z Basma, A Digesu, V Khullar - Biomedicines, 2023 - mdpi.com
Background: Polypropylene (PP) pelvic mesh is a synthetic mesh made of PP polymer used
to treat pelvic organ prolapse (POP). Its use has become highly controversial due to reports …

Macrophage polarization in response to ECM coated polypropylene mesh

MT Wolf, CL Dearth, CA Ranallo, ST LoPresti… - Biomaterials, 2014 - Elsevier
The host response to implanted biomaterials is a highly regulated process that influences
device functionality and clinical outcome. Non-degradable biomaterials, such as knitted …

Exploring the basic science of prolapse meshes

R Liang, K Knight, S Abramowitch… - Current Opinion in …, 2016 - journals.lww.com
Exploring the basic science of prolapse meshes : Current Opinion in Obstetrics and Gynecology
Exploring the basic science of prolapse meshes : Current Opinion in Obstetrics and Gynecology …

ECM hydrogel coating mitigates the chronic inflammatory response to polypropylene mesh

DM Faulk, R Londono, MT Wolf, CA Ranallo… - Biomaterials, 2014 - Elsevier
Polypropylene has been used as a surgical mesh material for several decades. This non-
degradable synthetic polymer provides mechanical strength, a predictable host response …

Vaginal degeneration following implantation of synthetic mesh with increased stiffness

R Liang, S Abramowitch, K Knight… - … Journal of Obstetrics …, 2013 - Wiley Online Library
Objective To compare the impact of the prototype prolapse mesh G ynemesh PS with that of
two new‐generation lower stiffness meshes, U ltra P ro and S mart M esh, on vaginal …

Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response

MT Wolf, CA Carruthers, CL Dearth… - … Research Part A: An …, 2014 - Wiley Online Library
Surgical mesh devices composed of synthetic materials are commonly used for ventral
hernia repair. These materials provide robust mechanical strength and are quickly …

Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo

KM Knight, GE King, SL Palcsey, A Suda, R Liang… - Acta biomaterialia, 2022 - Elsevier
Polypropylene meshes used in pelvic organ prolapse (POP) repair are hampered by
complications. Most POP meshes are highly unstable after tensioning ex vivo, as evidenced …

Characterization of the host inflammatory response following implantation of prolapse mesh in rhesus macaque

BN Brown, D Mani, AL Nolfi, R Liang… - American Journal of …, 2015 - Elsevier
Objective We sought to determine the predominant cell type (macrophage, T lymphocyte, B
lymphocyte, mast cell) within the area of implantation of the prototypical polypropylene …

Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque

R Liang, W Zong, S Palcsey, S Abramowitch… - American journal of …, 2015 - Elsevier
Objective The impact of polypropylene mesh implantation on vaginal collagen and elastin
metabolism was analyzed using a nonhuman primate model to further delineate the …