In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to
play critical regulatory roles in many processes. The major families of sRNAs include true …

Control of metal homeostasis is essential for life in all kingdoms. In most prokaryotic
organisms the FUR (ferric uptake regulator) family of transcriptional regulators is involved in …

Microorganisms play a dominant role in the biogeochemical cycling of nutrients. They are
rightly praised for their facility for fixing both carbon and nitrogen into organic matter, and …

Background Diverse bacterial genomes encode numerous small non-coding RNAs (sRNAs)
that regulate myriad biological processes. While bioinformatic algorithms have proven …

Bacteria are often exposed to a hostile environment and have developed a plethora of
cellular processes in order to survive. A burgeoning list of small non-coding RNAs (sRNAs) …

Sequencing-based studies have illuminated increased transcriptional complexity within the
genome structure of bacteria and have resulted in the identification of many small regulatory …

Small RNAs (sRNAs) that act by base-pairing have been shown to play important roles in
fine-tuning the levels and translation of their target transcripts across a variety of model and …

The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled
expression of a diverse array of virulence factors. The effects of host environments on the …

While iron is essential to sustain growth, its excess can be detrimental to the cell by
generating highly toxic reactive oxygen species. Regulation of iron homeostasis thus plays a …