Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

Twenty years ago, we first proposed our hypothesis on β-cell damage and its prevention (the
Okamoto model), according to which poly (ADP-ribose) synthetase/polymerase (PARP) …

Nicotinamide adenine dinucleotide (NAD+) has emerged as a key component in prokaryotic
and eukaryotic immune systems. The recent discovery that Toll/interleukin-1 receptor (TIR) …

Increases in [Ca 2+] i in pancreatic beta cells, resulting from Ca 2+ mobilization from
intracellular stores as well as Ca 2+ influx from extracellular sources, are important in insulin …

Human CD38 is a multifunctional protein involved in diverse functions. As an enzyme, it is
responsible for the synthesis of two Ca 2+ messengers, cADPR and NAADP; as an antigen …

CD38 is a type II transmembrane glycoprotein that is extensively expressed on cells of
bematopoietic and non‐hematopoietic lineage. Although the intracellular domain of CD38 is …

CD38 is a ubiquitous protein originally identified as a lymphocyte antigen and recently also
found to be a multifunctional enzyme participating in the synthesis and metabolism of two Ca …

Calcium (Ca2+) is a ubiquitous and fundamental signaling component that is utilized by
cells to regulate a diverse range of cellular functions, such as insulin secretion from …

We have established a protocol that allows for parallel quantification of three carbohydrate
pools in the marine diatom Phaeodactylum tricornutum. This method utilizes a series of …

ABSTRACT Aims/Introduction Imeglimin is a novel oral hypoglycemic agent that improves
blood glucose levels through multiple mechanisms of action including the enhancement of …