Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-
invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I …

Invariant Natural Killer T (iNKT) cells are a non-conventional, innate-like, T cell population
that recognize lipid antigens presented by the cluster of differentiation (CD) 1d molecule …

To broadly measure the spectrum of cellular self-antigens for natural killer T cells (NKT), we
developed a sensitive lipidomics system to analyze lipids trapped between CD1d and NKT T …

Pancreatic ductal adenocarcinoma (PDA) is a potentially lethal disease lacking effective
treatments. Its immunosuppressive tumor microenvironment (TME) allows it to evade host …

Bispecific T cell engagers (bsTCEs) hold great promise for cancer treatment but face
challenges due to the induction of cytokine release syndrome (CRS), on-target off-tumor …

The CD1 system binds lipid antigens for display to T cells. Here, we solved lipidomes for the
four human CD1 antigen-presenting molecules, providing a map of self-lipid display …

Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or
MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We …

The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-
associated degradation (ERAD), the unfolded protein response (UPR), and autophagy …

Obesity and related diseases have reached epidemic proportions and continue to rise.
Beyond creating an economical burden, obesity and its co-morbidities are associated with …

Invariant natural killer T (iNKT) cells are innate T cells that are recognized for their potent
immune modulatory functions. Over the last three decades, research in murine models and …