Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …

Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

Integrating neurons into digital systems may enable performance infeasible with silicon
alone. Here, we develop DishBrain, a system that harnesses the inherent adaptive …

Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …

Video-based screening of pooled libraries is a powerful approach for directed evolution of
biosensors because it enables selection along multiple dimensions simultaneously from …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …

The brain is arguably the most complex organ. The branched and extended morphology of
nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their …

Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the
neurophysiological mechanisms of DBS remain unclear. In awake mice, we performed high …

The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …