ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its
molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis …

The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …

Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …

Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by
protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). De-regulated …

The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is
known as Richter syndrome (RS), a rare event with dismal prognosis. In this study, we …