[HTML][HTML] A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects

YX Zhou, XH Gong, H Zhang, C Peng - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Increasing pharmacological evidence supports that paeoniflorin, a water-soluble
monoterpene glycoside isolated from Paeonia lactiflora Pall.(Shaoyao in Chinese), has a …

Bioavailability improvement strategies for icariin and its derivates: A review

R Szabó, CP Rácz, FV Dulf - International Journal of Molecular Sciences, 2022 - mdpi.com
In recent years, there has been considerable interest in icariin (ICA) and its derivates,
icariside II (ICS) and icaritin (ICT), due to their wide range of potential applications in …

[HTML][HTML] Bone mesenchymal stem cell-derived exosomes involved co-delivery and synergism effect with icariin via mussel-inspired multifunctional hydrogel for …

J Zeng, P Sun, Y Zhao, X Fang, Z Wu, X Qi - Asian Journal of …, 2023 - Elsevier
Mesenchymal stem cells (MSC) are particularly effective in promoting cartilage regeneration
due to their immunomodulatory, anti-inflammatory and regenerative repair functions of …

[HTML][HTML] Icariin and its metabolites as potential protective phytochemicals against cardiovascular disease: From effects to molecular mechanisms

Y Zeng, Y Xiong, T Yang, Y Wang, J Zeng… - Biomedicine & …, 2022 - Elsevier
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among all
types of diseases in the world, affecting many millions of individuals every year. CVD …

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Y Zu, Y Mu, Q Li, ST Zhang, HJ Yan - Journal of orthopaedic surgery and …, 2019 - Springer
Background Osteoarthritis (OA) is the common chronic degenerative joint bone disease that
is mainly featured by joint stiffness and cartilage degradation. Icariin (ICA), an extract from …

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy

X Ding, H Zhao, C Qiao - Phytomedicine, 2022 - Elsevier
Background Icariin (ICA) is a flavonoid extract obtained from Herba epimedii that has been
proven to exert multiple pharmacological activities, including antifibrotic and anti …

Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-κB signal pathway

M Qi, Y He, Y Cheng, Q Fang, R Ma, S Zhou, J Hao - Food & function, 2021 - pubs.rsc.org
Diabetic nephropathy (DN) is one of the complex and severe complications of diabetes
mellitus (DM). Icariin (ICA) is a flavonoid extracted from the leaves and stems of Herba …

Impact of Icariin and its derivatives on inflammatory diseases and relevant signaling pathways

Z Luo, J Dong, J Wu - International immunopharmacology, 2022 - Elsevier
Herba Epimedii is a famous herb collected from China and Korea. It has been used for
impotency, osteoporosis, and amnestic treatment for thousands of years. Icariin, a typical …

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

NA Alhakamy, UA Fahmy, SM Badr-Eldin, OAA Ahmed… - Pharmaceutics, 2020 - mdpi.com
Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has
cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to …

Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications

W Jiang, K Ding, R Yue, M Lei - Critical reviews in food science …, 2024 - Taylor & Francis
Diabetes mellitus (DM) is a global health issue in the twenty-first century, and there are
numerous challenges in preventing and alleviating its chronic complications. The herb …