Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

Ischemic stroke is one of the leading causes of death and long-term disability worldwide;
however, effective clinical approaches are still limited. The transcriptional factor Nrf2 is a …

Abstract Gabapentin (GBP), an analgesic, adjunct antiepileptic, and migraine prophylactic
drug, reduces neuronal injury induced by cerebral ischemia reperfusion (IR). However, the …

The most important activity of erythropoietin (EPO) is the regulation of erythrocyte production
by activation of the erythropoietin receptor (EPO-R), which triggers the activation of anti …

Ischemic brain injuries are accompanied by the long-term changes in gene expression in
the hippocampus, the limbic system structure, involved in the regulation of key aspects of the …

Reactive oxygen species generated via reperfusion cause lipid damage and induce lipid
peroxidation, leading to cerebral ischemia/reperfusion injury and exacerbation of cerebral …

Perinatal hypoxia-ischemia is one of the most common causes of perinatal brain injury and
subsequent neurological disorders in children. The aim of this work was to evaluate the …

Cerebral ischemia exhibits a multiplicity of pathophysiological mechanisms. During ischemic
stroke, the reactive oxygen species (ROS) concentration rises to a peak during reperfusion …

The central nervous system (CNS) injury, which occurs because of mechanical trauma or
ischemia/hypoxia, is one of the main causes of mortality and morbidity in the modern society …

Preterm infants are at high risk of brain injury. With more understanding of the preterm brain
injury's pathogenesis, neuroscientists are looking for more effective methods to prevent and …