Impulsivity is strongly associated with substance use disorders (SUDs). Our review
discusses impulsivity as an underlying vulnerability marker for SUDs, and treatment of co …

Addictive drugs have in common that they are voluntarily self-administered by laboratory
animals (usually avidly), and that they enhance the functioning of the reward circuitry of the …

As our understanding of the endocannabinoids improves, so does the awareness of their
complexity. During pathological states, the levels of these mediators in tissues change, and …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

A new mesopontine structure exerting a strong influence on dopamine systems has recently
been defined: the tail of the ventral tegmental area/rostromedial tegmental nucleus …

Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

The identification of the molecular mechanisms involved in nicotine addiction and its
cognitive consequences is a worldwide priority for public health. Novel in vivo paradigms …

Drug addiction is a chronic brain disorder leading to complex adaptive changes within the
brain reward circuits that involve several neurotransmitters. One of the neurochemical …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

The endogenous cannabinoid system is an important regulatory system involved in
physiological homeostasis. Endocannabinoid signaling is known to modulate neural …