The first steps in phage lysis involve a temporally controlled permeabilization of the
cytoplasmic membrane followed by enzymatic degradation of the peptidoglycan. For …

Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …

Bacteriophages have developed multiple host cell lysis strategies to promote release of
descendant virions from infected bacteria. This review is focused on the lysis mechanisms …

Mycobacterial infections are considered to a serious challenge of medicine, and the
emergence of MDR and XDR tuberculosis is a serious public health problem. Tuberculosis …

Holins form pores in the cytoplasmic membranes of bacteria for the primary purpose of
releasing endolysins that hydrolyze the cell wall and induce cell death. Holins are encoded …

The study of mycobacteriophages provides insights into viral diversity and evolution, as well
as the genetics and physiology of their pathogenic hosts. Genomic characterization of 80 …

Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium
smegmatis and Mycobacterium tuberculosis. The first mycobacteriophages were isolated in …

The mycobacterial cell wall presents significant challenges to mycobacteriophages–viruses
that infect mycobacterial hosts–because of its unusual structure containing a mycolic acid …

The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …

Recombineering, a recently developed technique for efficient genetic manipulation of
bacteria, is facilitated by phage-derived recombination proteins and has the advantage of …