The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …

The inbred mouse strain C57BL/6 has been widely used as a background strain for
spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Abstract C57BL/6J-related mouse strains are widely used animal models for diet-induced
obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce …

Obesity and its associated metabolic diseases are currently a priority research area. The
increase in global prevalence at different ages is having an enormous economic and health …

The relationship between marrow adipose tissue (MAT) and bone health is poorly
understood. We used running exercise to ask whether obesity‐associated MAT can be …

Background Eating disorders are lethal and heritable; however, the underlying genetic
factors are unknown. Binge eating is a highly heritable trait associated with eating disorders …

Abstract Objective The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic
research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt) …

Endothelial dysfunction is a critical, initiating step in the development of hypertension (HTN)
and mitochondrial reactive oxygen species (ROS) are important contributors to endothelial …

Obesity and metabolic syndrome pose a significant risk for developing cardiovascular
disease and remain a critical healthcare challenge. Given the lymphatic system's role as a …