A potent EGFR inhibitor, N-phenyl pyrazoline derivative suppresses aggressiveness and cancer stem cell-like phenotype of cervical cancer cells

Mustofa, PB Satriyo, AAT Suma… - Drug Design …, 2022 - Taylor & Francis
Objective Metastasis causes approximately 90% of cancer-related deaths, including in
cervical cancer patients. Uncontrolled cell proliferation, migration, and cancer stemness act …

Novel benzothiazole–pyrazoline–styrene hybrid for ultrasensitive detection of Hg (II) ions: Synthesis and chemosensor evaluation

D Ratnawati, I Kartini, HD Pranowo… - …, 2024 - Wiley Online Library
Water pollution has become a serious issue, and mercury (II) ion (Hg (II)) is highly toxic even
at low concentrations. Therefore, Hg (II) concentration should be strictly monitored. This …

Synthesis, characterization and molecular docking study of pyrazolines synthesized from chalcones: Antioxidant and acetylcholinesterase activities

IF de Farias, R de Oliveira Gonçalves… - Journal of Molecular …, 2023 - Elsevier
Pyrazolines are heterocyclic compounds with nitrogen-containing rings, known mainly for
their pharmacological potential. In recent times, much attention has been paid to the …

N-phenyl pyrazoline derivative inhibits cell aggressiveness and enhances paclitaxel sensitivity of triple negative breast cancer cells

PB Satriyo, M Mustofa, TD Wahyuningsih… - Scientific Reports, 2024 - nature.com
Protein kinase dysregulation induces cancer cell aggressiveness leading to rapid tumor
progression and poor prognosis in TNBC patients. Many small-molecule kinase inhibitors …

Molecular Docking Approach For Design and Synthesis of Thioxanthone Derivatives as Anticancer Agents

F Hermawan, Jumina, HD Pranowo… - …, 2022 - Wiley Online Library
Thioxanthone derivatives were docked, synthesized, and tested for their anticancer activity.
The molecular docking results showed that 1‐hydroxythioxanthone, 2‐chloro‐1 …

Towards targeting EGFR and COX-2 inhibitors: comprehensive computational studies on the role of chlorine group in novel thienyl-pyrazoline derivative

FF Wulan, TD Wahyuningsih, E Astuti… - Journal of Biomolecular …, 2024 - Taylor & Francis
To enhance the effectiveness of chemotherapy and overcome resistance, scientists must
develop novel drugs or scaffolds that have a combined effect, such as the inhibition of EGFR …

[HTML][HTML] Synthesis, molecular docking, ADMET profiling, and anti-PC3 activity of new Schiff base derivatives

DQ Kamil, AH Wasmi, WAALH Alhaidry… - Results in …, 2024 - Elsevier
Schiff bases are significant compounds that occur naturally or can be synthesized in
laboratory settings. In this study, we synthesized three novel Schiff bases, designated as …

Pyrazoline B-Paclitaxel or Doxorubicin Combination Drugs Show Synergistic Activity Against Cancer Cells: In silico Study

HL Wiraswati, MH Bashari, NM Alfarafisa… - … and Applications in …, 2024 - Taylor & Francis
Background Multidrug resistance in various cancer types is a major obstacle in cancer
treatment. The concept of a single drug molecular target often causes treatment failure due …

In-silico ANALYSIS OF N-PHENYL PYRAZOLINE DERIVATES AS POTENTIAL OF HUMAN EPIDERMAL GROWTH RECEPTOR-2 (HER-2) INHIBITOR USING …

D Satria, SB Waruwu, EN Sholikhah… - Rasayan Journal of …, 2024 - search.ebscohost.com
One of the most typical cancers to affect women worldwide is breast cancer. Multiple routes
involving different proteins that control the development of cancer. HER-2 is a protein that …

Novel Furan‐Pyrazole Molecular Hybrids as Prospective Anti‐Neuroinflammatory Agents: Design, Synthesis, and In‐Vitro Screening Thereof

S Mudimela, S Janardhanan - Asian Journal of Organic …, 2023 - Wiley Online Library
Neuro‐inflammatory responses lead to various neurodegenerative disorders. A small library
of 1H‐pyrazole‐1‐carbothioamidoacetamido)‐furan‐3‐carboxamide molecular hybrids …