Exercise intolerance remains a major unmet medical need in patients with heart failure (HF).
Skeletal myopathy is currently considered as the major limiting factor for exercise capacity in …

According to the World Health Organization, the population of over 60 will double in the next
30 years in the developed countries, which will enforce a further raise of the retirement age …

Background Advanced colorectal cancer (CRC) is often accompanied by the development of
liver metastases, as well as cachexia, a multi‐organ co‐morbidity primarily affecting skeletal …

Aims The heart rejuvenating effects of circulating growth differentiation factor 11 (GDF11), a
transforming growth factor-β superfamily member that shares 90% homology with myostatin …

Background Cardiac fibrosis stiffens the ventricular wall, predisposes to cardiac arrhythmias
and contributes to the development of heart failure. In the present study, our aim was to …

Muscle wasting, ie, cachexia, frequently occurs in cancer and associates with poor
prognosis and increased morbidity and mortality. Anticancer treatments have also been …

Objective Cancer cachexia and muscle loss are associated with increased morbidity and
mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has …

During exercise, the body's organs and skeletal muscles produce reactive oxygen species
(ROS). Excessive ROS can destroy cellular lipids, sugars, proteins, and nucleotides and …

Intrinsic and extrinsic inhibition of neuronal regeneration obstruct spinal cord (SC) repair in
mammals. In contrast, adult zebrafish achieve functional recovery after complete SC …

Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent
manifestation of PH but lacks any approved treatment. Activin receptor type IIA-Fc fusion …