[HTML][HTML] Endpoints for clinical trials in ophthalmology

L Schmetterer, H Scholl, G Garhöfer… - Progress in Retinal and …, 2023 - Elsevier
With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …

OCT angiography and its retinal biomarkers

TT Hormel, Y Jia - Biomedical Optics Express, 2023 - opg.optica.org
Optical coherence tomography angiography (OCTA) is a high-resolution, depth-resolved
imaging modality with important applications in ophthalmic practice. An extension of …

Biomarkers for the progression of intermediate age-related macular degeneration

EM Lad, RP Finger, R Guymer - Ophthalmology and Therapy, 2023 - Springer
Age-related macular degeneration (AMD) is a leading cause of severe vision loss
worldwide, with a global prevalence that is predicted to substantially increase. Identifying …

Pentosan polysulfate sodium-associated maculopathy: early detection using OCT angiography and choriocapillaris flow deficit analysis

MF Levin, A Santina, G Corradetti, A Au, A Lu… - American Journal of …, 2022 - Elsevier
Purpose To compare choriocapillaris flow deficit (CC-FD) analysis using optical coherence
tomography angiography (OCTA) in eyes of patients treated with high cumulative dosages of …

[HTML][HTML] Pushing Retinal Imaging Forward: Innovations and Their Clinical Meaning–The 2022 Ophthalmologica Lecture

E Borrelli, A Berni, L Mastropasqua, G Querques… - …, 2023 - karger.com
Retinal imaging has greatly expanded our understanding of various pathological conditions.
This article presents a summary of the key points covered during the 2022 Ophthalmologica …

Relationship between retinal fluid characteristics and vision in neovascular age-related macular degeneration: HARBOR post hoc analysis

SV Sadda, NM Holekamp, D Sarraf… - Graefe's Archive for …, 2022 - Springer
Purpose To evaluate the relationship between retinal fluid location, amount/severity, and
vision with ranibizumab-treated neovascular age-related macular degeneration (nAMD) …

An update on the hemodynamic model of age-related macular degeneration

PJ Rosenfeld, O Trivizki, G Gregori, RK Wang - American journal of …, 2022 - Elsevier
PURPOSE To provide an update on the hemodynamic model of age-related macular
degeneration (AMD). DESIGN Evidence-based perspective. METHODS Review of the …

Biomarkers in early response to brolucizumab on pigment epithelium detachment associated with exudative age-related macular degeneration

M Rispoli, CM Eandi, L Di Antonio, R Kilian, A Montesel… - Biomedicines, 2021 - mdpi.com
Background: The purpose of this study was to describe early changes in the morphology of
pigment epithelium detachments (PED) after an intravitreal injection of Brolucizumab into …

[HTML][HTML] The Impact of diabetic retinopathy on the choriocapillaris in neovascular AMD

P Viggiano, A Miere, E Borrelli, G Boscia… - … & Visual Science, 2023 - jov.arvojournals.org
Purpose: To investigate the impact of diabetic retinopathy (DR) on morphological
choriocapillaris (CC) modifications in eyes with type 1 macular neovascularization (MNV) …

OCT Prognostic Biomarkers for Progression to Late Age-related Macular Degeneration: A Systematic Review and Meta-analysis

M Trinh, R Cheung, A Duong, L Nivison-Smith… - Ophthalmology Retina, 2023 - Elsevier
Topic To evaluate which OCT prognostic biomarkers best predict the risk of progression from
early/intermediate to late age-related macular degeneration (AMD). Clinical Relevance …