Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

Innate immune cells are the early responders to infection and tissue damage. They play a
critical role in the initiation and resolution of inflammation in response to insult as well as …

Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but
their contributions to rapid clinical deterioration and dysregulated inflammation have not …

Neutrophils are critical mediators of both the initiation and resolution of inflammation after
myocardial infarction (MI). Overexuberant neutrophil signaling after MI exacerbates …

Inflammation plays a crucial role in the onset and development of atherosclerosis.
Periodontitis is a common chronic disease linked to other chronic inflammatory diseases …

Pyroptosis is a form of pro-inflammatory, necrotic cell death mediated by proteins of the
gasdermin family. Various heart diseases, including myocardial ischemia/reperfusion injury …

Background: Acute myocardial infarction (MI) results in overzealous production and
infiltration of neutrophils to the ischemic heart. This is mediated in part by granulopoiesis …

Objective: Platelets are central to acute myocardial infarction (MI). How the platelet proteome
is altered during MI is unknown. We sought to describe changes in the platelet proteome …

Heart failure threatens the lives of patients and reduces their quality of life. Heart failure,
especially heart failure with preserved ejection fraction, is closely related to systemic and …

Although modern clinical practices such as cesarean sections and perinatal antibiotics have
improved infant survival, treatment with broad-spectrum antibiotics alters intestinal …