Advances in RNA 3D structure modeling using experimental data
RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …
biological functions in a variety of molecular processes, including transcription, splicing …
The molecular structure of long non-coding RNAs: emerging patterns and functional implications
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …
cellular processes and are crucially connected to diseases. Despite their unprecedented …
Quantum computing algorithms: getting closer to critical problems in computational biology
L Marchetti, R Nifosì, PL Martelli… - Briefings in …, 2022 - academic.oup.com
The recent biotechnological progress has allowed life scientists and physicians to access an
unprecedented, massive amount of data at all levels (molecular, supramolecular, cellular …
unprecedented, massive amount of data at all levels (molecular, supramolecular, cellular …
Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery
In recent years, researchers have identified certain RNAs as druggable targets for small
molecules to treat several human pathologies. However, these regulatory RNAs are …
molecules to treat several human pathologies. However, these regulatory RNAs are …
RNA-Puzzles toolkit: a computational resource of RNA 3D structure benchmark datasets, structure manipulation, and evaluation tools
Significant improvements have been made in the efficiency and accuracy of RNA 3D
structure prediction methods during the succeeding challenges of RNA-Puzzles, a …
structure prediction methods during the succeeding challenges of RNA-Puzzles, a …
Advances in RNA 3D structure prediction
X Ou, Y Zhang, Y Xiong, Y Xiao - Journal of Chemical Information …, 2022 - ACS Publications
RNA molecules carry out various cellular functions, and understanding the mechanisms
behind their functions requires the knowledge of their 3D structures. Different types of …
behind their functions requires the knowledge of their 3D structures. Different types of …
G-Quadruplexes in the archaea domain
The importance of unusual DNA structures in the regulation of basic cellular processes is an
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) …
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) …
Screening strategies for identifying RNA-and ribonucleoprotein-targeted compounds
WJ Martin, P Grandi, M Marcia - Trends in Pharmacological Sciences, 2021 - cell.com
The past few years have witnessed important breakthroughs in the identification of
compounds that specifically bind and regulate RNAs and in optimizing them for therapeutic …
compounds that specifically bind and regulate RNAs and in optimizing them for therapeutic …
NMR-derived secondary structure of the full-length Ox40 mRNA 3′UTR and its multivalent binding to the immunoregulatory RBP Roquin
JN Tants, LM Becker, F McNicoll… - Nucleic acids …, 2022 - academic.oup.com
Control of posttranscriptional mRNA decay is a crucial determinant of cell homeostasis and
differentiation. mRNA lifetime is governed by cis-regulatory elements in their 3 …
differentiation. mRNA lifetime is governed by cis-regulatory elements in their 3 …
Computational tools to study RNA-protein complexes
S Bheemireddy, S Sandhya, N Srinivasan… - Frontiers in molecular …, 2022 - frontiersin.org
RNA is the key player in many cellular processes such as signal transduction, replication,
transport, cell division, transcription, and translation. These diverse functions are …
transport, cell division, transcription, and translation. These diverse functions are …