Anticancer steroids: linking natural and semi-synthetic compounds

JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Man-made cytotoxic steroids: exemplary agents for cancer therapy

R Bansal, PC Acharya - Chemical reviews, 2014 - ACS Publications
Cancer is one of the most dreaded diseases to haunt mankind in the world today. It is one of
the leading causes of death worldwide. Although overall cancer incidence rates in the …

Construction of cholesterol oxime ether derivatives containing isoxazoline/isoxazole fragments and their agricultural bioactive properties/control efficiency

H Xu, K Zhang, M Lv, M Hao - Journal of Agricultural and Food …, 2021 - ACS Publications
To explore natural-product-based pesticidal candidates and high value-added application of
cholesterol in agriculture, oximinoether derivatives of cholesterol-containing …

Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies (I)

JG Cui, L Fan, LL Huang, HL Liu, AM Zhou - Steroids, 2009 - Elsevier
The side chain of a compound plays an important role in its biological function. In our
studies, we have found that hydroximinosteroid derivatives with different side chains and …

Design, synthesis, and antitumor activity evaluation of steroidal oximes

AR Gomes, AS Pires, AM Abrantes… - Bioorganic & medicinal …, 2021 - Elsevier
Steroidal compounds were proven to be efficient drugs against several types of cancer.
Oximes are also chemical structures frequently associated with anticancer activity. The main …

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR

JFS Carvalho, MMC Silva, JN Moreira… - Journal of medicinal …, 2011 - ACS Publications
Chemically diverse oxysterols were prepared and evaluated for cytotoxicity, aiming to push
forward potency and selectivity. They were tested against seven cancer (HT-29, HepG2 …

Steroidal oximes: Useful compounds with antitumor activities

C Canario, S Silvestre, A Falcao… - Current medicinal …, 2018 - ingentaconnect.com
Background: Steroids play an important role in life because they can regulate a variety of
biological processes and have been widely used in medicine namely as antiinflammatory …

The structural diversity and biological activity of steroid oximes

AR Gomes, AS Pires, FMF Roleira… - Molecules, 2023 - mdpi.com
Steroids and their derivatives have been the subject of extensive research among
investigators due to their wide range of pharmacological properties, in which steroidal …

Recent advances in cholesterol chemistry

JW Morzycki - Steroids, 2014 - Elsevier
This review article presents advances in cholesterol chemistry since 2000. Various
transformations (chemical, enzymatic, electrochemical, etc.) of cholesterol are presented. A …

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

N Pathak, AS Negi - European Journal of Medicinal Chemistry, 2024 - Elsevier
Plants are rich in steroidal and triterpenoid saponins. Diosgenin is an important sapogenin
obtained from various steroidal saponins and specially from dioscin. It possesses diverse …