The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

Hypertensive nephropathy: unveiling the possible involvement of hemichannels and pannexons

CM Lucero, J Prieto-Villalobos… - International Journal of …, 2022 - mdpi.com
Hypertension is one of the most common risk factors for developing chronic cardiovascular
diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes …

Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy

Y Wang, Y Xu, C Zhou, Y Cheng, N Qiao, Q Shang… - Nature Medicine, 2024 - nature.com
Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of
major genetic variants in the etiology of CP, we conducted exome sequencing on a large …

[HTML][HTML] Role of astrocytes connexins-pannexins in acute brain injury

JE Tichauer, M Rovegno - Neurotherapeutics, 2025 - Elsevier
Acute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as
ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where …

Ambient PM2. 5 exposures and systemic inflammation in women with early pregnancy

B Zhang, X Gong, B Han, M Chu, C Gong… - Science of the Total …, 2022 - Elsevier
The association between ambient fine particulate matter (PM 2.5) and systemic inflammation
in women with early pregnancy is unclear. This study estimated the effects of PM 2.5 …

Single channel properties of pannexin‐1 and connexin‐43 hemichannels and P2X7 receptors in astrocytes cultured from rodent spinal cords

JM Garré, FF Bukauskas, MVL Bennett - Glia, 2022 - Wiley Online Library
Astrocytes express surface channels involved in purinergic signaling. Among these
channels, pannexin‐1 (Px1) and connexin‐43 (Cx43) hemichannels (HCs) release ATP that …

Connexins control glial inflammation in various neurological diseases

R Yamasaki - International journal of molecular sciences, 2023 - mdpi.com
Connexins (Cxs) form gap junctions through homotypic/heterotypic oligomerization. Cxs are
initially synthesized in the endoplasmic reticulum, then assembled as hexamers in the Golgi …

Genetically engineered neural stem cells (NSCs) therapy for neurological diseases; state‐of‐the‐art

G Lutfi Ismaeel, OJ Makki AlHassani… - Biotechnology …, 2023 - Wiley Online Library
Neural stem cells (NSCs) are multipotent stem cells with remarkable self‐renewal potential
and also unique competencies to differentiate into neurons, astrocytes, and …

Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood

MT Gervasi, R Romero, E Cainelli… - Journal of perinatal …, 2023 - degruyter.com
Objectives Intra-amniotic inflammation is a subclinical condition frequently caused by either
microbial invasion of the amniotic cavity or sterile inflammatory stimuli, eg, alarmins. An …

SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics

J Prieto-Villalobos, CM Lucero, M Rovegno… - Biological Research, 2023 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the
ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the …