Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

Human endogenous retroviruses (HERVs) are retroviruses that infected human genome
millions of years ago and have persisted throughout human evolution. About 8% of our …

Importance During the past few decades, the incidence of breast cancer (BC) has been
increasing rapidly in East Asia, and BC is currently the most common cancer in several …

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …

Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

Background Although APOBEC-mutational signature is found in tumor tissues of multiple
cancers, how a common germline APOBEC3A/B deletion affects the mutational signature …

Human papillomavirus (HPV) infection is a causative agent of multiple human cancers,
including cervical and head and neck cancers. In these HPV-positive tumors, somatic …

Background Heterogeneity of immune gene expression patterns of luminal breast cancer
(BC), which is clinically heterogeneous and overall considered as low immunogenic, has not …