Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

The neural mechanisms underlying memory regulation during sleep are not yet fully
understood. We found that melanin concentrating hormone–producing neurons (MCH …

Communication between the periphery and the brain is key for maintaining energy
homeostasis. To do so, peripheral signals from the circulation reach the brain via the …

Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals,
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …

The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that
is involved in the regulation of many behavioral and physiological processes including …

The lateral hypothalamic area (LHA) integrates homeostatic processes and reward-
motivated behaviors. Here we show that LHA neurons that produce melanin-concentrating …

This paper reviews evidence demonstrating a bidirectional relationship between memory
and eating in humans and rodents. In humans, amnesia is associated with impaired …