TP53 encodes a transcription factor that is centrally-involved in several pathways, including
the control of metabolism, the stress response, DNA repair, cell cycle arrest, senescence …

Summary p53 was discovered 45 years ago as an SV40 large T antigen binding protein,
coded by the most frequently mutated TP53 gene in human cancers. As a transcription …

Tumor genomes often harbor a complex spectrum of single nucleotide alterations and
chromosomal rearrangements that can perturb protein function. Prime editing has been …

Cancer research remains clinically unmet in many areas due to limited access to patient
samples and the lack of reliable model systems that truly reflect human cancer biology. The …

Despite the advanced technologies and global attention on cancer treatment strategies,
cancer continues to claim lives and adversely affects socio-economic development …

Mutations in the TP53 tumor suppressor gene are the most abundant genetic occurrences in
cancer. Some of these mutations lead to loss of function of p53 protein, some are gain of …

The p53 tumor suppressor gene governs a multitude of complex cellular processes that are
essential for anti-cancer function and whose dysregulation leads to aberrant gene …

In this issue of Cancer Discovery, companion articles from the Prives and Lozano groups
describe functional analyses of a common dimeric mutant of p53 found in Li–Fraumeni …

TP53 is the most frequently mutated gene in human cancer. While it is well understood that
the ability of p53 to act as a transcription factor is required for tumor suppression, the key …

In this study, by using the basic concepts and results of the Fuzzy Set Theory, the ambiguous
circumstances of homeopathy, regarding the selection, dilution, and potencies are analyzed …