As the most apical structure between epithelial and endothelial cells, tight junctions (TJ) are
well known as functioning as a control for the paracellular diffusion of ions and certain …

Epithelial and/or endothelial barriers play a critical role in animal, including human, life
forms. The tight junction (TJ) is an essential component of these barriers. Occludin is a major …

The β-catenin signaling pathway is deregulated in nearly all colon cancers.
Nonhypercalcemic vitamin D3 (1α, 25-dehydroxyvitamin D3) analogues are candidate drugs …

Mutations in the adenomatous polyposis coli or β-catenin gene lead to cytosolic
accumulation of β-catenin and, subsequently, to increased transcriptional activity of the β …

The tight junction proteins claudins are abnormally regulated in several human cancers. In
particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias …

Background & Aims: Paracellular transport varies widely among epithelia of the
gastrointestinal tract. We determined whether members of the claudin family of tight junction …

Epithelial tissues act as barriers between two fluid compartments, and the epithelial barrier
function is provided by the epithelial cells and the tight junctions (TJs) that connect them. We …

Purpose: Claudin proteins represent a large family of integral membrane proteins crucial for
tight junction (TJ) formation and function. Claudins have been shown to be up-regulated in …

Tight junction associated proteins are key molecular components governing cellular
adhesion, polarity and glandular differentiation. Tight junction proteins also play critical roles …

hDlg, the human homologue of the Drosophila D iscs-l ar ge (Dlg) tumor suppressor protein,
is known to interact with the tumor suppressor protein APC and the human papillomavirus …