Voltage-gated sodium (NaV) channels play a central role in the propagation of action
potentials in excitable cells in both humans and insects. Many venomous animals have …

Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

Loss-of-function mutations in the human voltage-gated sodium channel NaV1. 7 result in a
congenital indifference to pain. Selective inhibitors of NaV1. 7 are therefore likely to be …

Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity,
with 47,000 described species and an estimated 150,000 species in existence. Evolving …

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that
exhibit unique pharmacological properties to modulate key membrane protein targets …

The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high
structural stability and functional diversity. Here, we describe a new scorpion venom-derived …

Voltage-gated sodium channels (NaVs) are a key determinant of neuronal signalling.
Neurotoxins from diverse taxa that selectively activate or inhibit NaV channels have helped …

The present study was designed to search for compounds with analgesic activity from the
Schizophyllum commune (SC), which is widely consumed as edible and medicinal …

Centipedes are one of the oldest venomous arthropods using toxin as their weapon to
capture prey. But little attention was focused on them and only few centipede toxins were …

Ion channels play a key role in our body to regulate homeostasis and conduct electrical
signals. With the help of advances in structural biology, as well as the discovery of numerous …