Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

The adenosine A2A receptor subtype is recognized as a non-dopaminergic
pharmacological target for the treatment of neurodegenerative disorders, notably …

The human adenosine A2B receptor (A2BR) is a class AG protein–coupled receptor that is
involved in several major physiological and pathological processes throughout the body …

The A2A adenosine receptor is a protein belonging to a family of four GPCR adenosine
receptors. It is involved in the regulation of several pathophysiological conditions in both the …

Obesity occurs when overall energy intake surpasses energy expenditure. White adipose
tissue is an energy storage site, whereas brown and beige adipose tissues catabolize stored …

The discovery and clinical implementation of modulators of adenosine, P2Y and P2X
receptors (comprising nineteen subtypes) have progressed dramatically in∼ 50 years since …

The tumor microenvironment regulates many aspects of cancer progression and anti-tumor
immunity. Cancer cells employ a variety of immunosuppressive mechanisms to dampen …

Abstract Scientists Robert J. Lefkowitz and Brian K. Kobilka won the Nobel Prize in 2012 for
reporting a groundbreaking discovery that revealed a crucial member of the receptor family …

Along with the increase in life expectancy, a significant increase of people suffering from
neurodegenerative diseases (ND) has been noticed. The second most common ND, after …

All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of
purinergic receptors includes adenosine receptors. Four distinct G-protein-coupled …