As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

Objective: The goal of this study was to examine the clinical presentation of chronic
traumatic encephalopathy (CTE) in neuropathologically confirmed cases. Methods: Thirty-six …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
repetitive mild traumatic brain injury. It is defined pathologically by the abnormal …

Abstract Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable
identification of individuals at high and low risk of AD. However, there is little agreement in …

Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens of
millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen …

The APOE gene is one of currently only two genes that have consistently been associated
with longevity. Apolipoprotein E (APOE) is a plasma protein which plays an important role in …

The heritability of Alzheimer's disease estimated from twin studies is greater than the
heritability derived from genome-based studies, for reasons that remain unclear. We apply …

Age‐related macular degeneration (AMD) is the most common cause of incurable visual
impairment in high‐income countries. Previous studies report inconsistent associations …

Introduction Alzheimer's disease (AD) is accompanied by metabolic alterations both in the
periphery and the central nervous system. However, so far, a global view of AD‐associated …