Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

To identify itch-related mediators and receptors that are differentially expressed in pruritic
skin, we used RNA sequencing to analyze the complete transcriptome in skin from paired …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …