A research agenda for ageing in China in the 21st century: Focusing on basic and translational research, long-term care, policy and social networks
One of the key issues facing public healthcare is the global trend of an increasingly ageing
society which continues to present policy makers and caregivers with formidable healthcare …
society which continues to present policy makers and caregivers with formidable healthcare …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
Periodontitis and accelerated biological aging: A geroscience approach
G Baima, M Romandini, F Citterio… - Journal of Dental …, 2022 - journals.sagepub.com
As the whole world is epidemically aging, the burden of periodontitis and tooth loss is
becoming a major health concern. Growing meta-epidemiological data implicate chronic …
becoming a major health concern. Growing meta-epidemiological data implicate chronic …
Nrf2: Molecular and epigenetic regulation during aging
A Silva-Palacios, M Ostolga-Chavarría, C Zazueta… - Ageing research …, 2018 - Elsevier
Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …
APOE Alleles and Extreme Human Longevity
P Sebastiani, A Gurinovich, M Nygaard… - The Journals of …, 2019 - academic.oup.com
We assembled a collection of 28,297 participants from seven studies of longevity and
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …
healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene …
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood …
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously
associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune …
associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune …
Plasma proteomic profile of age, health span, and all‐cause mortality in older adults
Aging is a complex trait characterized by a diverse spectrum of endophenotypes. By utilizing
the SomaScan® proteomic platform in 1,025 participants of the LonGenity cohort (age …
the SomaScan® proteomic platform in 1,025 participants of the LonGenity cohort (age …
Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
Comparing biomarker profiles measured at similar ages, but earlier in life, among
exceptionally long-lived individuals and their shorter-lived peers can improve our …
exceptionally long-lived individuals and their shorter-lived peers can improve our …
NIA Long Life family study: Objectives, design, and heritability of cross-sectional and longitudinal phenotypes
MK Wojczynski, S Jiuan Lin, P Sebastiani… - The Journals of …, 2022 - academic.oup.com
Abstract The NIA Long Life Family Study (LLFS) is a longitudinal, multicenter, multinational,
population-based multigenerational family study of the genetic and nongenetic determinants …
population-based multigenerational family study of the genetic and nongenetic determinants …
Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan
B Milholland, J Vijg - Nature Aging, 2022 - nature.com
The purpose of this Perspective is to clarify for an interdisciplinary audience the fundamental
concepts of human longevity and provide evidence for a limit to human lifespan. This …
concepts of human longevity and provide evidence for a limit to human lifespan. This …