Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …
substrates, controls several signaling pathways, and is implicated in a plethora of human …
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death
DW Litchfield - Biochemical Journal, 2003 - portlandpress.com
Protein kinase CK2 ('casein kinase II') has traditionally been classified as a messenger-
independent protein serine/threonine kinase that is typically found in tetrameric complexes …
independent protein serine/threonine kinase that is typically found in tetrameric complexes …
CK2 regulation: perspectives in 2021
SE Roffey, DW Litchfield - Biomedicines, 2021 - mdpi.com
The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …
serine/threonine kinases that phosphorylate substrates involved in numerous biological …
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
Although the C-terminal cytoplasmic tail of the tight junction protein occludin is heavily
phosphorylated, the functional impact of most individual sites is undefined. Here, we show …
phosphorylated, the functional impact of most individual sites is undefined. Here, we show …
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice …
W Gong, J Li, Z Chen, J Huang, Q Chen, W Cai… - Free Radical Biology …, 2017 - Elsevier
Our previous study indicated that Casein kinase 2 interacting protein-1 (CKIP-1) could
promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …
promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …
How can a traffic light properly work if it is always green? The paradox of CK2 signaling
CK2 is a constitutively active protein kinase that assuring a constant level of phosphorylation
to its numerous substrates supports many of the most important biological functions …
to its numerous substrates supports many of the most important biological functions …
An extensive survey of CK2 α and β subunits in Arabidopsis: multiple isoforms exhibit differential subcellular localization
Abstract Casein kinase 2 (CK2) is a ubiquitous enzyme essential for the viability of
eukaryotic cells. In the present work we analyzed the Arabidopsis thaliana genome in a …
eukaryotic cells. In the present work we analyzed the Arabidopsis thaliana genome in a …
Cancer-type dependent expression of CK2 transcripts
MMJ Chua, M Lee, I Dominguez - PloS one, 2017 - journals.plos.org
A multitude of proteins are aberrantly expressed in cancer cells, including the oncogenic
serine-threonine kinase CK2. In a previous report, we found increases in CK2 transcript …
serine-threonine kinase CK2. In a previous report, we found increases in CK2 transcript …
Protein kinase CK2 and SARS-CoV-2: An expected interplay story
CP Quezada Meza, M Ruzzene - Kinases and Phosphatases, 2023 - mdpi.com
Protein kinase CK2 is a Ser/Thr protein kinase that phosphorylates hundreds of substrates
mainly related to survival and proliferation pathways. It has long been considered an anti …
mainly related to survival and proliferation pathways. It has long been considered an anti …
[HTML][HTML] Comparison of CX-4945 and SGC-CK2-1 as inhibitors of CSNK2 using quantitative phosphoproteomics: Triple SILAC in combination with inhibitor-resistant …
Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase
signalling. Since inhibitor-resistant kinase mutants (ie, drug-resistant alleles) remain active …
signalling. Since inhibitor-resistant kinase mutants (ie, drug-resistant alleles) remain active …