Hepatic encephalopathy (HE) is a neuropsychiatric syndrome derived from metabolic
disorders due to various liver failures. Clinically, HE is characterized by hyperammonemia …

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most
common chronic hepatic disorder worldwide in both adults and children. It is well …

Lifestyle factors have been acknowledged to be modifiable targets that can be used to
counter the increasing prevalence of depression. This study aims to investigate combining …

Obesity is a risk factor for cognitive dysfunction and neurodegenerative disease, including
Alzheimer's disease (AD). The gut microbiota-brain axis is altered in obesity and linked to …

Metabolic-associated steatohepatitis (MASH) and ulcerative colitis (UC) exhibit a complex
interconnection with immune dysfunction, dysbiosis of the gut microbiota, and activation of …

Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden,
and it is currently gaining increasing interest in relation to its potential impact on central …

Objective Kallistatin (KST), also known as SERPIN A4, is a circulating, broadly acting human
plasma protein with pleiotropic properties. Clinical studies in humans revealed reduced KST …

Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic
diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate …

Background & Aims Cognitive dysfunction is an increasingly recognised manifestation of
metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanistic link …

Background Non-alcoholic fatty liver disease (NAFLD) has been linked to cognitive decline
and neuropsychiatric conditions, implying a potential connection between NAFLD and brain …