Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent
vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory …

Recent evidence demonstrates that tobacco smoking causes an imbalance in bone
turnover, leading to lower bone mass and making bone vulnerable to osteoporosis and …

Symptoms of depression can be induced in humans through blockade of
acetylcholinesterase (AChE) whereas antidepressant-like effects can be produced in animal …

Genetic variants responsible for susceptibility to obesity and its comorbidities among
Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …

The hedonic properties of food can stimulate feeding behaviour even when energy
requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic …

Aims/hypothesis The anatomic location of excess body fat has an impact on associated
cardiometabolic morbidity, and visceral adipose tissue (VAT) is more pathogenic than …