Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Lithium treatment over the lifespan in bipolar disorders

C Volkmann, T Bschor, S Köhler - Frontiers in Psychiatry, 2020 - frontiersin.org
Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70
years. It is recommended by all relevant guidelines as a first-line treatment for maintenance …

Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition

X Liu, A Verma, G Garcia Jr… - Proceedings of the …, 2021 - National Acad Sciences
The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …

ILAE clinical practice recommendations for the medical treatment of depression in adults with epilepsy

M Mula, MJ Brodie, B de Toffol, A Guekht… - …, 2022 - Wiley Online Library
The aim of this document is to provide evidence‐based recommendations for the medical
treatment of depression in adults with epilepsy. The working group consisted of members of …

Glycogen synthase kinase 3β: a new gold rush in anti-Alzheimer's disease Multitarget Drug Discovery? Miniperspective

A De Simone, V Tumiatti, V Andrisano… - Journal of Medicinal …, 2020 - ACS Publications
Alzheimer's disease (AD), like other multifactorial diseases, is the result of a systemic
breakdown of different physiological networks. As result, several lines of evidence suggest …

Prevention of suicidal behavior in bipolar disorder

L Tondo, GH Vázquez, RJ Baldessarini - Bipolar disorders, 2021 - Wiley Online Library
Background Excess mortality is a critical hallmark of bipolar disorder (BD) due to co‐
occurring general medical disorders and especially from suicide. It is timely to review of the …

Lithium's antiviral effects: a potential drug for CoViD-19 disease?

A Murru, M Manchia, T Hajek, RE Nielsen… - International Journal of …, 2020 - Springer
Background Since its introduction in modern medicine, naturalistic observations emerged
about possible uses of lithium treatment for conditions different from recurring affective …

Lithium enrichment optimization from Dead Sea end brine by chemical precipitation technique

A Alsabbagh, S Aljarrah, M Almahasneh - Minerals Engineering, 2021 - Elsevier
Lithium and its compounds are widely utilized in many applications like batteries, aircraft
alloys, ceramics, nuclear reactors, medicine, and metallurgy additives due to its exceptional …

The need for establishing best practices and gold standards in psychedelic medicine

A Feduccia, G Agin-Liebes, CM Price, N Grinsell… - Journal of Affective …, 2023 - Elsevier
Psychedelic substances are under investigation in several drug development programs.
Controlled clinical trials are providing evidence for safe and effective use of psychedelic …

Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients

R Santos, SB Linker, S Stern, APD Mendes… - Molecular …, 2021 - nature.com
Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic
episodes that affect 2% of the world population. The first-line long-term treatment for mood …