Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the
small size of these lesions, affected individuals can have hundreds to thousands of cerebral …

Implantable neural microelectrodes that can record extracellular biopotentials from small,
targeted groups of neurons are critical for neuroscience research and emerging clinical …

What is the nature of the vascular architecture in the cortex that allows the brain to meet the
energy demands of neuronal computations? We used high-throughput histology to …

The human brain is the organ with the highest metabolic activity but it lacks a traditional
lymphatic system responsible for clearing waste products. We have demonstrated that the …