Discovered as antiviral cytokines, interferons (IFNs) are now also recognized for their
capacity to inhibit the growth of malignant cells via activation of programmed cell death …

ABSTRACT Inositol 1, 4, 5-trisphosphate 3-kinase (IP 3 3-kinase/IP3K) plays an important
role in signal transduction in animal cells by phosphorylating inositol 1, 4, 5-trisphosphate …

Mammalian cells produce a variety of inositol phosphates (InsPs), including Ins (1, 4, 5) P 3
that serves both as a second messenger and as a substrate for inositol polyphosphate …

< 1> Canis familiaris (isozymes A and B [1])[1]< 2> Rattus norvegicus (male rats [48];
Sprague-Dawley rats [40]; ST1A1 [40, 48]; AST IV [48]; aryl sulfotransferase IV [32, 48]; a …

Inositol-1, 4, 5-trisphosphate 3-kinases (IP3K) A, B, and C as well as inositol polyphosphate
multikinase (IPMK) catalyze the first step in the formation of the higher phosphorylated …

The release of Ca2+ from intracellular stores is triggered by the second messenger inositol
(1, 4, 5)-trisphosphate (Ins (1, 4, 5) P3). The regulation of this process is critically important …

Many neutrophil functions are regulated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns
(3, 4, 5) P3) that mediates protein membrane translocation via binding to pleckstrin homolog …

At present targeted tumor therapy is based on inhibition of proteins or protein mutants that
are up-regulated in tumor but not in corresponding normal cells. The actin bundling Inositol …

Organismal stress responses to oxidative stress are relevant to ageing and disease and
involve key cell-/tissue-specific signal transduction mechanisms. Using Drosophila, an …

Inositol 1, 4, 5-trisphosphate [Ins (1, 4, 5) P 3] 3-kinase catalyses the phosphorylation of Ins
P 3 to inositol 1, 3, 4, 5-tetrakisphosphate. cDNAs encoding three human isoenzymes of Ins …