The management of heart failure with reduced ejection fraction (HF-REF) has improved
significantly over the last two decades. In contrast, little or no progress has been made in …

Cardiac disease in diabetes mellitus and in the metabolic syndrome consists of both
vascular and myocardial abnormalities. The latter are characterised predominantly by …

Aims/hypothesis Hyperglycaemia and insulin resistance have been linked to diastolic
dysfunction experimentally. We investigated the association between glucose metabolism …

Background Comorbidities negatively affect prognosis more strongly in heart failure with
preserved (HFpEF) than with reduced (HFrEF) ejection fraction. Their comparative impact on …

Isolated diastolic dysfunction is found in almost half of asymptomatic patients with well-
controlled diabetes and may precede diastolic heart failure. However, mechanisms that …

Diabetic cardiomyopathy and heart failure have been recognized as the leading causes of
mortality among diabetics. Diabetic cardiomyopathy has been characterized primarily by the …

Aim: Diabetic cardiomyopathy is an increasingly recognized entity. The pathogenic factors
that may contribute to its development, especially the earliest changes of diastolic …

Insulin resistance is a characteristic feature of type 2 diabetes and congestive heart failure.
Evidence is now emerging regarding the potential for oxidative stress to play a causal role in …

Aims To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients.
Methods 439 hypertensive patients were selected for participation in this study. All …

Our aims were to study left ventricular (LV) function and myocardial blood flow reserve
(MBFR) in long-term type 1 diabetes and associations with advanced glycation end products …