Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
[HTML][HTML] Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy
The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of
placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and …
placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and …
Mechanisms of lung injury induced by SARS-CoV-2 infection
The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here,
we outline the multistep mechanisms of lung epithelial and endothelial injury induced by …
we outline the multistep mechanisms of lung epithelial and endothelial injury induced by …
Communications between macrophages and cardiomyocytes
P Yang, Z Chen, W Huang, J Zhang, L Zou… - Cell Communication and …, 2023 - Springer
The heart is a muscular organ that pumps blood throughout the body and is one of the most
vital organs in human body. While cardiomyocytes are essential for maintaining the normal …
vital organs in human body. While cardiomyocytes are essential for maintaining the normal …
[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …
that outcomes are markedly heterogeneous between patients. This requires identifying the …
Microfluidic organ-chips and stem cell models in the fight against COVID-19
S Satta, SJ Rockwood, K Wang, S Wang… - Circulation …, 2023 - Am Heart Assoc
SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …
3D human tissue models and microphysiological systems for HIV and related comorbidities
DE Yin, AC Palin, TB Lombo, RN Mahon, B Poon… - Trends in …, 2024 - cell.com
Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …
[HTML][HTML] An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages
Rationale: Macrophages are the frontline immune cells in response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …
Investigating and resolving cardiotoxicity induced by COVID‐19 treatments using human pluripotent stem cell‐derived cardiomyocytes and engineered heart tissues
H Xu, G Liu, J Gong, Y Zhang, S Gu, Z Wan… - Advanced …, 2022 - Wiley Online Library
Coronavirus disease 2019 continues to spread worldwide. Given the urgent need for
effective treatments, many clinical trials are ongoing through repurposing approved drugs …
effective treatments, many clinical trials are ongoing through repurposing approved drugs …