Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain
where, remarkably, it is estimated to make up 1–5% of total neuronal protein. Although it …

Objective To determine whether serum neurofilament light (NfL) correlates with CSF NfL,
traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor …

Sustained silencing of gene expression throughout the brain using small interfering RNAs
(siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA …

Background The proteins S100B, neuron-specific enolase (NSE), glial fibrillary acidic
protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and neurofilament light …

Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …

Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in
traumatic brain injury (TBI) management. The aim of this study was to determine how …

Background In order to improve assessment and outcome prediction in patients suffering
from traumatic brain injury (TBI), cerebral protein levels in serum have been suggested as …

There is growing public concern surrounding traumatic brain injury (TBI). TBI can cause
significant morbidity, and the long-term sequelae are poorly understood. TBI diagnosis and …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple
organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are …