The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …

We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

T cells are key elements of cancer immunotherapy but certain fundamental properties, such
as the development and migration of T cells within tumours, remain unknown. The enormous …

T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …

Chimeric antigen receptor (CAR) T cells have proven that engineered immune cells can
serve as a powerful new class of cancer therapeutics. Clinical experience has helped to …

The antitumour activity of endogenous or adoptively transferred tumour-specific T cells is
highly dependent on their differentiation status. It is now apparent that less differentiated T …

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis
point to distinct immunological pathways that drive disease relapses and progression. In …

Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …