Recent clinical trials have demonstrated that the immense majority of acute promyelocytic
leukemia (APL) patients can be definitively cured by the combination of two targeted …

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML)
that is cytogenetically characterized by a balanced reciprocal translocation between …

Abstract Cullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various
physiological and pathological processes, including neoplastic events. The substrate …

Background Plant homeodomain (PHD) fingers are central “readers” of histone post-
translational modifications (PTMs) with> 100 PHD finger-containing proteins encoded by the …

A deeper understanding of colorectal cancer (CRC) biology would help to identify specific
early diagnostic markers. Here, we conducted quantitative proteomics on FFPE healthy …

Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation
therapy, with a minority of patients experiencing treatment failure and even early death. We …

PHRF1 is an E3 ligase that promotes TGF-β signaling by ubiquitinating a homeodomain
repressor TG-interacting factor (TGIF). The suppression of PHRF1 activity by PML-RARα …

A prominent function of TGIF 1 is suppression of transforming growth factor beta (TGF‐β)
signaling, whose inactivation is deemed instrumental to the progression of pancreatic ductal …

Acute myeloid leukaemia (AML) is a rapidly fatal blood cancer that is characterised by the
accumulation of immature myeloid cells in the blood and bone marrow as a result of blocked …

All-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO) administration leads to
granulocytic maturation and/or apoptosis of acute promyelocytic leukemia (APL) cells mainly …