Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a
critical role in innate immunity. We summarize how NETs are formed in response to various …

Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in
two distinct flavors-primitive and definitive. Definitive RBCs in mammals circulate as smaller …

Erythroid cells undergo enucleation and the removal of organelles during terminal
differentiation,,. Although autophagy has been suggested to mediate the elimination of …

ERYTHROPOIETIN (EP) is a glycoprotein produced primarily by the kidney, and is the
principal factor regulating red blood cell (RBC) production. 1 Unlike most of the …

Background: Simple epithelia encase developing embryos and organs. Although these
epithelia consist of only one or two layers of cells, they must provide tight barriers for the …

BACKGROUND: Not long after the Big Bang, iron began to play a central role in the
Universe and soon became mired in the tangle of biochemistry that is the prima essentia of …

In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive
during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus …

Hematopoiesis is the physiological process where hematopoietic stem cells (HSCs)
continuously generate the body's complement of blood and immune cells within unique …

Mammalian erythroid cells undergo enucleation, an asymmetric cell division involving
extrusion of a pycnotic nucleus enveloped by the plasma membrane,,. The mechanisms that …