[HTML][HTML] Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold

J Bojarska, A Mieczkowski, ZM Ziora, M Skwarczynski… - Biomolecules, 2021 - mdpi.com
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …

[HTML][HTML] Advancements in the preparation of high-performance liquid chromatographic organic polymer monoliths for the separation of small-molecule drugs

X Ding, J Yang, Y Dong - Journal of Pharmaceutical Analysis, 2018 - Elsevier
The various advantages of organic polymer monoliths, including relatively simple
preparation processes, abundant monomer availability, and a wide application range of pH …

Enhanced solubility, dissolution, and permeability of abacavir by salt and cocrystal formation

X Ji, D Wu, C Li, J Li, Q Sun, D Chang, Q Yin… - Crystal Growth & …, 2021 - ACS Publications
Abacavir (ABC) is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase
inhibitor specifically prescribed for the treatment of HIV infection. However, as a BCS class III …

New salts and cocrystals of pymetrozine with improvements on solubility and humidity stability: Experimental and theoretical study

D Wu, J Li, Y Xiao, X Ji, C Li, B Zhang… - Crystal Growth & …, 2021 - ACS Publications
For the purpose of enhancing the solubility and humidity stability of pymetrozine (PMZ), a
highly active but nonbiocidal pesticide, new multicomponent crystals were developed based …

Structural and computational insights into cocrystal interactions: a case on cocrystals of antipyrine and aminophenazone

D Yang, R Wang, G Jin, B Zhang, L Zhang… - Crystal Growth & …, 2019 - ACS Publications
This study aimed to gain insight into cocrystal interactions through solid-state
characterization and theoretical computation. We formulated four novel cocrystalline phases …

[HTML][HTML] Structural and biofunctional insights into the Cyclo (Pro-Pro-Phe-Phe-) Scaffold from experimental and in silico studies: Melanoma and beyond

J Bojarska, M Breza, M Remko, M Czyz… - International Journal of …, 2022 - mdpi.com
Short peptides have great potential as safe and effective anticancer drug leads. Herein, the
influence of short cyclic peptides containing the Pro-Pro-Phe-Phe sequence on patient …

Solid-state luminescence properties, Hirshfeld surface analysis and DFT calculations of mononuclear lanthanide complexes (Ln= EuIII, GdIII, TbIII, DyIII) containing 4 …

LL Cai, YT Hu, Y Li, K Wang, XQ Zhang, G Muller… - Inorganica chimica …, 2019 - Elsevier
Four mononuclear lanthanide complexes containing 4′-phenyl-2, 2′: 6′, 2 ″-terpyridine
(ptpy),[Ln (NO 3) 3 (ptpy)(H 2 O)](Ln= Eu (1), Gd (2), Tb (3), Dy (4)), were solvothermally …

[HTML][HTML] Supramolecular synthon hierarchy in cyclopropyl-containing peptide-derived compounds

J Bojarska, M Breza, M Remko, P Borowiecki… - …, 2022 - pubs.rsc.org
Considering the increasing importance of cyclopropyl-containing peptide-derived
compounds in the pharmaceutical industry, herein, we report the crystal engineering of a …

The experimental and theoretical landscape of a new antiplatelet drug ticagrelor: Insight into supramolecular architecture directed by CH⋯ F, π⋯ π and CH⋯ π …

J Bojarska, M Remko, A Fruziński… - Journal of Molecular …, 2018 - Elsevier
The crystal and molecular structure landscape of a new drug ticagrelor has been
investigated by using experimental and theoretical approach. The structures of this …

[HTML][HTML] The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective

J Bojarska, R New, P Borowiecki, M Remko… - Frontiers in …, 2021 - frontiersin.org
Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC)
is a powerful approach in the fight against diverse viruses, including SARS-CoV-2 …