A high-performance system for robust stain normalization of whole-slide images in histopathology

A Anghel, M Stanisavljevic, S Andani… - Frontiers in …, 2019 - frontiersin.org
Stain normalization is an important processing task for computer-aided diagnosis (CAD)
systems in modern digital pathology. This task reduces the color and intensity variations …

Thresholds of toxicological concern–Setting a threshold for testing below which there is little concern

T Hartung - ALTEX-Alternatives to animal experimentation, 2017 - altex.org
Low dose, low risk; very low dose, no real risk. Setting a pragmatic threshold below which
concerns become negligible is the purpose of thresholds of toxicological concern (TTC). The …

Testosterone, cortisol, hGH, and IGF‐1 levels in an Italian female elite volleyball team

L Roli, S De Vincentis, MBL Rocchi… - Health science …, 2018 - Wiley Online Library
Purpose To assess the transferability of the reference intervals (RI) of testosterone (T),
cortisol (C), human growth hormone (hGH), and insulin‐like growth factor (IGF)‐1, calculated …

[HTML][HTML] A new generalization of the inverse generalized Weibull distribution with different methods of estimation and applications in medicine and engineering

IA Alsaggaf, SF Aloufi, LA Baharith - Symmetry, 2024 - mdpi.com
Limitations inherent to existing statistical distributions in capturing the complexities of real-
world data often necessitate the development of novel models. This paper introduces the …

Development and validation of the Gastrointestinal Symptom Severity Scale in Spanish children and adolescents

N Montoro-Pérez, AE Martínez-González… - European Journal of …, 2024 - Springer
Functional gastrointestinal disorders (FGIDs) are characterized by chronic or recurrent
gastrointestinal symptoms (GS) that are not explained by structural or biochemical …

Utilisation of parametric methods to improve percentile-based estimates for the carcinogenic potency of nitrosamines

R Thomas, A Thresher, DJ Ponting - Regulatory Toxicology and …, 2021 - Elsevier
N-Nitrosamines have recently been the subject of intense regulatory scrutiny, including the
setting of low exposure limits (18 ng/day)(European Medicines Agency (EMA), 2020). This …

[HTML][HTML] A new index of a water temperature equivalent for summer respiration conditions of benthic invertebrates in rivers as a bio-indicator of global climate change

A Sundermann, A Müller, M Halle - Limnologica, 2022 - Elsevier
Detailed information on species temperature preferences are needed to measure the effects
of global warming on species and communities in European rivers. However, information …

[HTML][HTML] Nitrosamine acceptable intakes should consider variation in molecular weight: The implication of stoichiometric DNA damage

J Fine, L Allain, J Schlingemann, DJ Ponting… - Regulatory Toxicology …, 2023 - Elsevier
N-nitrosamines (NAs) are a class of compounds of which many, especially of the small
dialkyl type, are indirect acting DNA alkylating mutagens. Their presence in pharmaceuticals …

The effect of non-neovascular age-related macular degeneration on face recognition performance

DJ Taylor, ND Smith, AM Binns, DP Crabb - Graefe's archive for clinical …, 2018 - Springer
Purpose There is a well-established research base surrounding face recognition in patients
with age-related macular degeneration (AMD). However, much of this existing research …

A composite autonomic index as unitary metric for heart rate variability: a proof of concept

R Sala, M Malacarne, N Solaro… - European journal of …, 2017 - Wiley Online Library
Background This study addresses whether a unitary cardiac autonomic nervous system
index (ANSI), obtained combining multiple metrics from heart rate variability (HRV) into a …