The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic
inflammation and allergic diseases. They exert their biological effects by binding to specific …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Aspirin-Exacerbated Respiratory Disease About 7% of patients with asthma have mucosal
swelling, nasal polyps, and worsening of asthma in response to aspirin and other COX-1 …

Asthma endotypes are constantly evolving. Currently, there are no universally accepted
criteria to define endotypes. The TH 2-high endotype can have either allergic or nonallergic …

The potential of precision medicine in allergy and asthma has only started to be explored. A
significant clarification in the pathophysiology of rhinitis, chronic rhinosinusitis, asthma, food …

Objective The recent development of endotypes to categorize disease variants of chronic
rhinosinusitis (CRS) reflects an evolving understanding of the various pathophysiologic and …

Background Nasal polyps influence the burden of aspirin-exacerbated respiratory disease
(AERD) by contributing to eicosanoid production. AERD is diagnosed through graded …

Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by
the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective …

Allergic diseases of the (upper and lower) airways, the skin and the gastrointestinal tract, are
on the rise, resulting in impaired quality of life, decreased productivity, and increased …