Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Summary Background The London patient (participant 36 in the IciStem cohort) underwent
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …

Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV)
replication and improves immune function, but is unable to eradicate the virus. Therefore …

The HIV latent reservoir forms the major hurdle to an HIV cure. The discovery of CD32 as
marker of this reservoir has aroused much interest, but subsequent reports have challenged …

Precise delivery of genes to therapy-relevant cells is crucial for in vivo gene therapy.
Receptor-targeting as prime strategy for this purpose is limited to cell types defined by a …

Greater than 90% of HIV-1 proviruses are thought to be defective and incapable of viral
replication. While replication competent proviruses are of primary concern with respect to …

Fc receptors are involved in a variety of physiologically and disease-relevant responses.
Among them, FcγRIIA (CD32a) is known for its activating functions in pathogen recognition …

Deciphering the mechanisms underlying viral persistence is critical to achieving a cure for
human immunodeficiency virus (HIV) infection. Here, we implement a systems approach to …

Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) are
associated with severe perturbations in the gut mucosal environment characterized by …