Novel agents and drug targets to meet the challenges of resistant fungi

MW McCarthy, DP Kontoyiannis… - The Journal of …, 2017 - academic.oup.com
The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …

[HTML][HTML] Antifungal proteins: more than antimicrobials?

N Hegedüs, F Marx - Fungal biology reviews, 2013 - Elsevier
Antimicrobial proteins (AMPs) are widely distributed in nature. In higher eukaryotes, AMPs
provide the host with an important defence mechanism against invading pathogens. AMPs …

Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets

S Liu, Y Hou, W Liu, C Lu, W Wang, S Sun - Eukaryotic cell, 2015 - Am Soc Microbiol
In recent years, the emergence of fungal resistance has become frequent, partly due to the
widespread clinical use of fluconazole, which is minimally toxic and effective in the …

The antifungal action mode of the rice endophyte Streptomyces hygroscopicus OsiSh-2 as a potential biocontrol agent against the rice blast pathogen

T Xu, L Cao, J Zeng, CMM Franco, Y Yang, X Hu… - Pesticide biochemistry …, 2019 - Elsevier
Microbial antagonists and their bioactive metabolites provide one of the best alternatives to
chemical pesticides to control crop disease for sustainable agriculture and global food …

Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent …

S Liu, Y Hou, X Chen, Y Gao, H Li, S Sun - International journal of …, 2014 - Elsevier
The past decades have witnessed a dramatic increase in invasive fungal infections,
especially candidiasis. Despite the development of more effective new antifungal agents …

Novel findings about the mode of action of the antifungal protein PeAfpA against Saccharomyces cerevisiae

M Giner-Llorca, A Locascio, JA Del Real… - Applied microbiology …, 2023 - Springer
Antifungal proteins (AFPs) from filamentous fungi offer the potential to control fungal
infections that threaten human health and food safety. AFPs exhibit broad antifungal spectra …

Sanxiapeptin, a linear pentapeptide from Penicillium oxalicum, inhibited the growth of citrus green mold

YC Yang, K Li, CX Liu, F Cheng, C Liu, WJ Quan… - Food Chemistry, 2022 - Elsevier
Penicillium oxalicum has been used as a biocontrol fungus in agriculture for many years, but
the antimicrobial substances are still uncertain. Herein, we isolated a linear peptide named …

Searching for the optimal fluorophore to label antimicrobial peptides

C Zhao, A Fernandez, N Avlonitis… - ACS Combinatorial …, 2016 - ACS Publications
With the advent of antimicrobial resistance, there is an urgent need for new strategies to treat
infectious diseases. Antimicrobial peptides are considered as promising candidates, and …

NFAP2, a novel cysteine-rich anti-yeast protein from Neosartorya fischeri NRRL 181: isolation and characterization

L Tóth, Z Kele, A Borics, LG Nagy, G Váradi, M Virágh… - Amb Express, 2016 - Springer
The increasing incidence of fungal infections and damages due to drug-resistant fungi urges
the development of new antifungal strategies. The cysteine-rich antifungal proteins from …

Evaluation of the ecotoxicity of pollutants with bioluminescent microorganisms

F Fernández-Piñas, I Rodea-Palomares… - … and Applications in …, 2014 - Springer
This chapter deals with the use of bioluminescent microorganisms in environmental
monitoring, particularly in the assessment of the ecotoxicity of pollutants. Toxicity bioassays …